FINDINGS

Sourced from: https://www.cedars-sinai.org/newsroom/research-alert-artificial-sweeteners-significantly-alter-the-small-bowel-microbiome/

Cedars-Sinai investigators examined the potential effects of consuming non-sugar sweeteners, including both non-aspartame non-sugar sweeteners and aspartame alone, on the composition of the stool and duodenal microbiomes. Compared to controls in the study, scientists noted significant differences in both stool and duodenal (small intestine) microbial diversity and composition. Levels of circulating inflammatory markers were also altered in participants who consumed non-aspartame non-sugar sweeteners as well as those using aspartame only.

BACKGROUND

More than 140 million people in the United States use sugar substitutes, according to data from the U.S. Census Bureau. Sucralose, aspartame, saccharin and the plant-based stevia leaf extract are among the most popular. These artificial sweeteners are frequently used by people trying to reduce their sugar intake or lower calories from sugar for weight management. But there are increasing concerns about the potential health risks associated with the use of non-sugar substitutes based on data suggesting they do not help with long-term weight loss and may be linked to higher risks for Type 2 diabetes, heart disease and death. There are also questions about the potential negative effects the sugar substitutes may have on the gut microbiome, which plays a vital role in overall health.

In a controlled study, Cedars-Sinai investigators analyzed and compared the duodenal luminal microbiome in subjects consuming artificial sweeteners, aspartame alone or no sugar substitutes. The stool microbiome in some of these subjects was also compared.

METHOD

Investigators obtained samples from a small group of adults undergoing standard of care esophagogastroduodenoscopy without colon prep. All enrolled subjects provided duodenal luminal aspirates as well as fasting blood samples for analysis, and a subset also provided optional stool samples. Scientists analyzed the duodenal luminal microbiome in subjects consuming non-aspartame non-sugar sweeteners (NANS, N=35), aspartame only (ASP, N=9), and controls (CON, N=55), and the stool microbiome in a subset (N=40).

IMPACT

Artificial sweeteners are associated with a variety of changes depending on the area of the intestine. Significantly, the effects of these substances on the gut microbiome differ in the small bowel compared to the large bowel. These changes may be potentially important for health and warrant future study.

Disclaimer: This article was sourced from Cedars-Sinai. A nonprofit academic healthcare organization serving the diverse Los Angeles community and beyond.